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About the Program

Overview

The Systems Biology for EnteroPathogens program is is combining high-throughput experimental 'omics' technologies with computational modeling of metabolic and transcriptional regulatory networks to systematically study the related bacteria Salmonella and Yersinia under model conditions of virulence.

Funded by the National Institute of Allergy and Infectious Diseases component of the National Institutes of Health, this highly collaborative effort involves a diverse staff and a number of integrated research projects at the following institutions.

EMSL
Proteomics, metabolomics, and lipidomics measurements are being performed in the Environmental Molecular Sciences Laboratory (EMSL), a US Department of Energy scientific user facility on the PNNL campus.
  • Pacific Northwest National Laboratory, program coordination and application of mass-spectrometry-based proteomics, metabolomics and lipidomics.
  • The University of California, San Diego, genome-based reconstructions of pathogen metabolic and transcriptional pathways.
  • Oregon Health and Science University, Salmonella experiments, mutagenesis and sample development.
  • University of Texas Medical Branch at Galveston, Yersinia experiments, mutagenesis and sample development.
  • The J. Craig Venter Institute, transcriptional microarray and other analyses as needed.
  • Washington State University Tri-Cities, identification support of key metabolites and lipids.

Systems Biology

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Fundamental & Computational Sciences

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